The Mechanism of Adenine Thiomethylriroside Formation* by F. Schlenk and Raymond
نویسنده
چکیده
In earlier papers (l-3) we have reported that the accumulation of adenine thiomethylriboside (5’-thiomethyladenosine) in yeast depends upon the presence of methionine in the culture medium. The mechanism of the reaction has now been studied and some of the results will be reported here. Attempts were made to determine the size of the fragment contributed by methionine toward formation of the nucleoside (see Scheme A). Incorporation of part of the methionine molecule into the carbohydrate part
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Response of Aerobacter aerogenes methionine auxotrophs to adenine thiomethyl compounds.
It has been shown that many microorganisms produce thiomethyl adenosine from methionine (Smith and Schlenk, 1952). This prompted biochemical studies on the relationship between methionine and thiomethyl adenosine, which resulted in the discovery of methionyl adenosine as the key intermediate (Catoni, 1952; Schlenk, 1952). Replacement of methionine by thiomethyl adenosine has not been demonstrat...
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